BS ISO 20046:2019 Radiological protection. Performance criteria for laboratories using Fluorescence In Situ Hybridization (FISH) translocation assay for assessment of exposure to ionizing radiation

BS ISO 20046:2019

Radiological protection. Performance criteria for laboratories using Fluorescence In Situ Hybridization (FISH) translocation assay for assessment of exposure to ionizing radiation

Status : Current   Published : March 2019

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PDF

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HARDCOPY



What is this standard about?

The purpose of this document is to provide criteria for quality assurance (QA), quality control (QC) and evaluation of the performance of biological dosimetry by cytogenetic service laboratories.

This document addresses:

a) the responsibilities of both the customer and the laboratory;

b) the confidentiality of personal information, for the customer and the laboratory;

c) the laboratory safety requirements;

d) sample processing; culturing, staining and scoring, including the criteria for scoring for translocation analysis by FISH;

e) the calibration sources and calibration dose ranges useful for establishing the reference dose-response curves that contribute to the dose estimation from chromosome aberration frequency and the detection limit;

f) the scoring procedure for translocations stained by FISH used for evaluation of exposure;

g) the criteria for converting a measured aberration frequency into an estimate of absorbed dose (also appears as “dose”);

h) the reporting of results;

i) the QA and QC;

j) Annexes A to F containing sample instructions for the customer, sample questionnaire, sample datasheet for recording aberrations, sample of report and fitting of the low dose-response curve by the method of maximum likelihood and calculating the uncertainty of dose estimate.




Standard NumberBS ISO 20046:2019
TitleRadiological protection. Performance criteria for laboratories using Fluorescence In Situ Hybridization (FISH) translocation assay for assessment of exposure to ionizing radiation
StatusCurrent
Publication Date20 March 2019
Normative References(Required to achieve compliance to this standard)No other standards are normatively referenced
Informative References(Provided for Information)ISO 5725-5, ISO 5725-1, GUM:1995, ISO 17099, ISO/IEC Guide 98-3, ISO 13528, ISO 19238, ISO 11929, ISO 5725-2
International RelationshipsISO 20046:2019
Draft Superseded By18/30329940 DC
DescriptorsMeasuring instruments, Photons, Dosimeters, Portable, Manually-operated devices, Radiation protection, Identification methods, Spectroscopy, Performance, Detectors, Neutrons, Radioactive materials, Radionuclides, Radiation measurement
ICS13.280
Title in FrenchRadioprotection. Critères de performance pour les laboratoires utilisant l'analyse des translocations visualisées par hybridation in situ fluorescente (FISH) pour évaluer l'exposition aux rayonnements ionisants
CommitteeNCE/2
ISBN978 0 580 91588 8
PublisherBSI
FormatA4
DeliveryYes
Pages50
File Size1.607 MB
Price£240.00


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