ASTM E1242 - 97(2014) - Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis

ASTM E1242 - 97(2014)

Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis

Status : Current   Published : January 2014

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1.1 This practice covers a procedure for estimating the fathead minnow ( Pimephales promelas) 96-h LC50 of nonreactive (that is, covalently bonded without unsaturated residues) and nonelectrolytic (that is, require vigorous reagents to facilitate substitution, addition, replacement reactions and are non-ionic, non-dissociating in aqueous solutions) organic chemicals acting solely by narcosis, also referred to as Meyer-Overton toxicity relationship. 2

1.2 This procedure is accurate for organic chemicals that are toxic due to narcosis and are non-reactive and non-electrolytic. Examples of appropriate chemicals are: alcohols, ketones, ethers, simple halogenated aliphatics, aromatics, and aliphatic substituted aromatics. It is not appropriate for chemicals whose structures include a potential toxiphore (that structural component of a chemical molecule that has been identified to show mammalian toxicity, for example CN is known to be reponsible for inactivation of enzymes, NO 2 for decoupling of oxidative phosphorylation, both leading to mammalian toxicity). Examples of inappropriate chemicals are: carbamates, organophosphates, phenols, beta-gamma unsaturated alcohols, electrophiles, and quaternary ammonium salts.




Standard NumberASTM E1242 - 97(2014)
TitleStandard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis
StatusCurrent
Publication Date10 January 2014
Normative References(Required to achieve compliance to this standard)No other standards are normatively referenced
Informative References(Provided for Information)No other standards are informatively referenced
Descriptors Aquatic Organisms, Chemicals, Organic, Other, Diseases And Conditions, Environmental Hazard Assessment, Lethal Concentration, Meyer-Overton Toxicity, Narcosis, Octanol-Water Partition Coefficient, Organic Chemicals, Partition Coefficient, Pimephales Promelas, Toxicity
ICS07.080
PublisherASTM
FormatA4
DeliveryYes
Pages2
File Size60 KB
Price£36.00


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